2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Z8447
    9(E)-Erythromycin A oxime
    		Control
    (9E)-Erythromycin A oxime is a metabolite of Roxithromycin (HY-B0435). Roxithromycin is a semi-synthetic macrolide antibiotic.
    9(E)-Erythromycin A oxime
  • HY-174439
    Nsp12-IN-2
    Nsp12-IN-2 (Compound 8), the triphosphate metabolite of 4'-thiouridine (HY-W113081), is a SARS-CoV-2 Nsp12 inhibitor. Nsp12-IN-2 inhibits the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, terminates RNA synthesis and also blocks the RNAylation and NMPylation of Nsp9. Nsp12-IN-2 is promising for research of infections caused by SARS-CoV-2, other coronaviruses, and other RNA viruses.
    Nsp12-IN-2
  • HY-118788
    N-Desmethyl rosiglitazone
    N-Desmethyl rosiglitazone (SB 237216) is a metabolite of Rosiglitazone (HY-17386), generated through demethylation by the cytochrome P450 enzyme system in liver microsomes. It retains partial PPARγ agonist activity and supports studies on the metabolism and pharmacokinetics of Rosiglitazone (HY-17386).
    N-Desmethyl rosiglitazone
  • HY-W588248
    DL-Sulforaphane glutathione
    DL-Sulforaphane glutathione (DL-SFN-GSH) is a metabolite of Sulforaphane (HY-13755) in rat plasma.
    DL-Sulforaphane glutathione
  • HY-W716865
    CBNQ
    CBNQ (Compound 22; Cannabinolquinone; HU-345) is an oxidative product of cannabinol.
    CBNQ
  • HY-Z18056
    Norpropranolol hydrochloride
    Norpropranolol hydrochloride is the active metabolite of Propranolol (HY-B0573B).
    Norpropranolol hydrochloride
  • HY-167638
    Fenretinide glucuronide
    Fenretinide glucuronide (4-HPR-O-glucuronide) is a metabolite formed from Fenretinide (HY-15373) through glucuronidation. The formation of Fenretinide glucuronide enhances the water solubility of Fenretinide and facilitates its excretion. Fenretinide glucuronide holds potential for research in the field of cancer.
    Fenretinide glucuronide
  • HY-Z2338
    5-O-Desmethyl omeprazole
    5-O-Desmethyl omeprazole is a metabolite of Omeprazole by cytochrome P450.
    5-O-Desmethyl omeprazole
  • HY-W007577R
    4-Nitrobenzaldehyde (Standard)
    4-Nitrobenzaldehyde (Standard) is the analytical standard of 4-Nitrobenzaldehyde (HY-W007577). This product is intended for research and analytical applications. 4-Nitrobenzaldehyde is a widely used industrial chemical intermediate and also the main photodegradation product of the broad-spectrum antibiotic Chloramphenicol (HY-B0239). 4-Nitrobenzaldehyde has genotoxic and mutagenic effects and poses a certain threat to human health and ecosystems.
    4-Nitrobenzaldehyde (Standard)
  • HY-130498
    DDOH
    DDOH is an effective metabolite of DTT. DDOH can combine with palmitic acid to form conjugates.
    DDOH
  • HY-G0006R
    Omeprazole sulfide (Standard)
    Omeprazole sulfide (Standard) is the analytical standard of Omeprazole sulfide. This product is intended for research and analytical applications. Omeprazole sulfide is an Esomeprazole (HY-17021) precursor. Omeprazole sulfide can be converted to Esomeprazole by Lysinibacillus sp. B71. Esomeprazole can inhibit gastric H+/+ ATP enzyme. Omeprazole sulfide is mainly used in gastroesophageal reflux disease, gastric ulcer and antibacterial research.
    Omeprazole sulfide (Standard)
  • HY-131272R
    Febuxostat dicarboxylic acid impurity (Standard)
    Febuxostat dicarboxylic acid impurity (Standard) is the analytical standard of Febuxostat dicarboxylic acid impurity. This product is intended for research and analytical applications. Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat dicarboxylic acid impurity (Standard)
  • HY-W587771
    Mono-2-ethyl-5-carboxypentyl terephthalate
    Mono-2-ethyl-5-carboxypentyl terephthalate (MECPTP) is a major metabolite of Di-2-ethylhexyl terephthalate (DEHTP). Mono-2-ethyl-5-carboxypentyl terephthalate is promising for research of metabolic liver diseases, such as nonalcoholic fatty liver disease (NAFLD).
    Mono-2-ethyl-5-carboxypentyl terephthalate
  • HY-129903R
    N-Desethyl vardenafil (Standard)
    N-Desethyl vardenafil (Standard) is the analytical standard of N-Desethyl vardenafil. This product is intended for research and analytical applications. N-Desethyl vardenafil is the major metabolite of Vardenafil (HY-B0442) and can be detected in human urine.
    N-Desethyl vardenafil (Standard)
  • HY-176991
    Desmethyl-K777
    Desmethyl-K777 is a one of the main metabolites of K777 (HY-119293).
    Desmethyl-K777
  • HY-130569S1
    7-Hydroxymethotrexate-d3
    7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    7-Hydroxymethotrexate-d<sub>3</sub>
  • HY-W144096R
    Methyl 2,4,6-trihydroxybenzoate (Standard)
    Methyl 2,4,6-trihydroxybenzoate is a metabolite of 2,4,6-trihydroxybenzoate and exhibits properties as an antioxidant, lipid lowering and anticancer activities.
    Methyl 2,4,6-trihydroxybenzoate (Standard)
  • HY-W010143
    (R,S)-Norcotinine
    (R,S)-Norcotinine ((Rac)-Norcotinine) is the racemic mixture of Norcotinine. (R,S)-Norcotinine is a biomarker of secondhand smoke exposure and is associated with the toxic mechanisms of secondhand smoke on cardiovascular development.
    (R,S)-Norcotinine
  • HY-113452
    3-Hydroxysuberic acid
    3-Hydroxysuberic acid is a Suberic acid (HY-W015300) metabolite with serum downregulation in obese individuals. 3-Hydroxysuberic acid associates with colorectal and lung cancer. 3-Hydroxysuberic acid can be used for the research of colorectal cancer and lung cancer.
    3-Hydroxysuberic acid
  • HY-A0019R
    Paliperidone (Standard)
    Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.
    Paliperidone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity